Low expression of miR-142-3p promotes intervertebral disk degeneration
نویسندگان
چکیده
منابع مشابه
miR‑142‑3p promotes osteoblast differentiation by modulating Wnt signaling.
Canonical Wnt signaling is critical for the control of osteoblast differentiation in human mesenchymal stem cells. MicroRNAs (miRs) are essential regulators of cell differentiation by post‑transcriptional regulation of target gene expression. The aim of the present study was to investigate the molecular mechanism by which miR‑142‑3p promotes osteoblastic differentiation using the human fetal os...
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BACKGROUND/AIMS An increasing number of studies show that microRNAs (miRNAs) play crucial roles in nasopharyngeal carcinoma (NPC) tumorigenesis. The aim of our study was to investigate the biological roles and mechanisms of miR-142-3p in NPC. METHODS miR- 142-3p expression was examined in NPC specimens and nasopharyngitis biopsy samples by quantitative real-time PCR. The biological functions ...
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At present, the molecular evidence involved in the degeneration of the IVD is still in its primitive stage. In general, however, intrinsic, extrinsic, and generic factors all have shown a contribution to the initiation of degeneration. These factors may stimulate cytokines and directly or indirectly generate the cellular events thus far detected and observed. Such changes discussed have been th...
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N.L. Marinelli V.M. Haughton P.A. Anderson BACKGROUND AND PURPOSE: T2 relaxation times provide a continuous measure of changes in intervertebral disk biochemistry. The purpose of this study was to correlate T2 relaxation times in lumbar disks with patient age and stage of degeneration. MATERIALS AND METHODS: Sagittal T1and T2-weighted images and axial images were acquired in 20 patients referre...
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Intervertebral disk degeneration is a common and potentially debilitating disease process affecting millions of Americans and other populations each year. Current treatments address resultant symptoms and not the underlying pathophysiology of disease. This has spawned the development of biologic treatments, such as gene therapy, which attempt to correct the imbalance between catabolism and anab...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Surgery and Research
سال: 2021
ISSN: 1749-799X
DOI: 10.1186/s13018-020-02194-4